Read at: PubMedĬlark K, Goldstein R, Maron B, Breu AC.
Tadalafil for veterans with chronic obstructive pulmonary disease-pulmonary hypertension: A multicenter, placebo-controlled randomized trial. Maron BA, Choudhary G, Goldstein RL, Garshick E, Jankowich M, Tucker TJS, LaCerda KA, Hattler B, Dempsey EC, Sadikot RT, Shapiro S, Rounds SI, Goldstein RH. Real-world use of inhaled treprostinil for lung disease-pulmonary hypertension: A protocol for patient evaluation and prescribing. Johnson SW, Finlay L, Mathai SC, Goldstein RH, Maron BA. Research special interests include: Pulmonary Matrix Biology related to Pulmonary Fibrosis and EmphysemaĬlinical special interests include: Pulmonary Fibrosis We participate in several clinical studies to evaluate the efficacy of these agents in the pathogenesis of IPF. In human studies, our clinical experimental interest involves the use of novel substances to treat idiopathic pulmonary fibrosis (IPF). We have extensive experience in the diagnosis and management of individuals with pulmonary fibrosis.
These approaches are studied in wild type and transgenic murine models of emphysema and fibrosis. Employing the techniques of cellular and molecular biology, we are developing methods to modulating the levels of collagen, elastin and other key matrix substances in the alveolar wall. The loss of matrix substances results in emphysema whereas the excessive deposition of matrix substances results in pulmonary fibrosis. Our laboratory is exploring the regulation of the alveolar matrix during the development of early emphysema and fibrosis.
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